New paper out! “Development of a sustainable continuous flow approach toward allantoin”, published in Journal of Flow Chemistry

Our colleague Elena Salvadeo worked in collaboration with Jean-Christophe Monbaliu (Citos, University of Liege) on a new way to produce Allantoin in flow chemistry.


Allantoin is a commodity molecule widely used in cosmetic and pharmaceutical industry for its moisturizing properties. Although allantoin is a naturally occurring compound, its extraction is not economically viable on the industrial scale. Its production relies on urea and glyoxylic acid as starting materials. Current methods need long reaction times and use additives that raise safety and environmental issues. This work presents a novel process toward allantoin that uses Design of Experiments (DoE) and flow chemistry techniques. Intensified continuous flow conditions enable the preparation of high purity allantoin with a productivity of isolated product of 4.65 g h−1. The research of alternative and more environmental friendly additives for the preparation of allantoin emphasizes that glyoxylic acid itself (in slight excess) is an effective catalyst for the reaction, paving the way to the development of more sustainable synthetic processes.


Deep Tech Pioneer

Among 5000 participants from 128 countries, Alysophil has been selected Deep Tech Pioneer in the Hello Tomorrow challenge. This is a new recognition of our ideas! The adventure continues. Come and meet us on March 12 and 13, 2020 at the Hello Tomorrow Summit in Paris.